Phencyclidine-induced catalepsy in pigeons: specificity and stereoselectivity.
نویسندگان
چکیده
A procedure is described for the rapid assessment of cataleptic activity (loss of righting, without head-drop and without eye closure) of phencyclidine-type drugs. Single- and cumulative-dosing procedures with phencyclidine and ketamine produced similar results. Pentobarbital produced loss of righting at doses which also induced head-drop and eye closure. Catalepsy was induced exclusively by the d-isomers of ketamine, 1-(1-phenylcyclohexyl)-3-methylpiperidine and alpha-dioxadrol. The procedure is suitable for studying compounds which may interact with phencyclidine receptors.
منابع مشابه
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عنوان ژورنال:
- European journal of pharmacology
دوره 106 3 شماره
صفحات -
تاریخ انتشار 1984